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. 2018 Mar 4;2018:6079642. doi: 10.1155/2018/6079642

Figure 3.

Figure 3

hucMSC-Ex reduced oxidative stress in mouse liver fibrosis. (a) Representative images of H&E and Masson staining of mouse fibrotic livers after PBS or hucMSC-Ex treatment. Reduced steatosis and collagen deposition were observed in the hucMSC-Ex group. Original magnification 200x. (b) Quantitative analyses of collagen I and III mRNA expression after hucMSC-Ex treatment (n = 10; ∗P < 0.05, ∗∗P < 0.01). (c) Immunohistochemistry analysis of 8-OHdG and activated caspase 3 after administration of PBS or hucMSC-Ex. Original magnification 200x. (d, e) MDA and TGF-β levels were measured in homogenates of a mouse fibrotic liver treated with PBS and hucMSC-Ex. The levels of MDA and TGF-β were inhibited by hucMSC-Ex compared with the PBS group (n = 10; ∗P < 0.05).