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. Author manuscript; available in PMC: 2018 Mar 18.
Published in final edited form as: Nature. 2017 Jul 31;548(7668):466–470. doi: 10.1038/nature23470

Extended Data Figure 6. STING knockout in B16-F10 impairs IR-induced inflammatory gene expression in vitro and the abscopal response after in vivo irradiation of contralateral tumor.

Extended Data Figure 6

a, RT- and b, cGAMP-induced gene induction is absent in STING knockout B16 cells. c, Injection of B16 parental or STING knockout cells (+/− RT) without combination anti-CTLA4 treatment is insufficient to induce an abscopal effect. d, Overall survival of mice when B16 parental or STING knockout were injected after indicated treatment. All mice received anti-CTLA4 antibody. P-value calculated by log-rank test. e, B16 tumors are injected into opposite flanks of mice and treated as indicated. The index tumor is irradiated with 20Gy and both the index and abscopal tumors are measured starting on day 11 post-injection. f, irradiation of the index tumor leads to an abscopal response that is dependent on STING (left panel). This response is not seen in unirradiated mice (right panel).