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. Author manuscript; available in PMC: 2018 Mar 18.
Published in final edited form as: Nature. 2017 Jul 31;548(7668):466–470. doi: 10.1038/nature23470

Extended Data Figure 1. Non-homologous end-joining inhibition impedes DSB-induced inflammatory signaling.

Extended Data Figure 1

a, Total STAT1 protein levels are increased in a time-dependent manner after IR. b, U2OS cells were monitored for STAT1 activation during recovery from I-PpoI nuclease. c, Gene expression changes were monitored for indicated genes during recovery from I-PpoI damage in MCF10A cells (see figure 1c). d, Prostate epithelial cells (PREC) were analyzed for STAT1 phosphorylation at 6 days following 10Gy. e, STAT1 phosphorylation following IFNβ1 treatment is not DNA-PK or CDK1 dependent. f, pSTAT1 activation measured by western blot is unchanged by ATMi. DNA-PKi and ATMi block phosphorylation of DNA-PKcs-Ser2056 and pKAP1-S824, respectively as measured by western blot.