Table 3. Pathways of E. coli differentially regulated when exposed to both M. xanthus OMVs and culture Supernatant compared to the Prey Starvation 2 experimental condition.

Down-regulated	Up-regulated
OMV and Supernatant
eco02010 : ABC transporters	eco00010 : Glycolysis/gluconeogenesis
eco02020 : Two-component system	eco00052 : Galactose metabolism
	eco00230 : Purine metabolism
	eco00240 : Pyrimidine metabolism
	eco00260 : Glycine, serine and threonine metabolism
	eco00521 : Streptomycin biosynthesis
	eco02010 : ABC transporters
	eco02060 : Phosphotransferase system (PTS)
	eco03010 : Ribosome