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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Brain Behav Immun. 2017 Nov 8;69:113–123. doi: 10.1016/j.bbi.2017.11.005

Figure 1. Repeated social defeat caused mechanical allodynia and social avoidance.

Figure 1

Male C57BL/6 mice were subjected to six days of repeated social defeat (Stress) or left undisturbed as controls (Con). Mice were tested for social avoidance 12 hours after the sixth day of stress. Time spent in the A) interaction zone and B) corner zone are shown. In a separate experiment, mice were tested for mechanical allodynia prior to stress exposure and 12 hours after the first, third, and sixth day of RSD. Additionally, mice were tested for mechanical allodynia one week following termination of stress. C) Withdrawal threshold of mechanical stimulation to the hind paw using the von Frey behavior test. Bars represent average ± SEM. Means with (*) are significantly different from Con (p<0.05).