Table 3.
Mean Blood Cell Counts and Percentages by DII Quartiles Stratified by Body Mass Index Status, National Health and Nutrition Examination Survey (NHANES), 2005–2014.
| Immune Marker | Quartile 1 (n=6,491) | Quartile 2 (n=6,599) | Quartile 3 (n=6,608) | Quartile 4 (n=6,348) | P-value 1 vs. 4 | P-value Cont. |
|---|---|---|---|---|---|---|
| BMI <25.0 | ||||||
|
| ||||||
| WBC Count (1000 per uL) | 6.88 (6.67–7.10) | 6.84 (6.64–7.05) | 7.09 (6.89–7.30) | 7.12 (6.90–7.34) | 0.01 | <0.01 |
| Lymphocyte Count (1000 per uL) | 2.12 (2.04–2.20) | 2.07 (1.98–2.16) | 2.11 (2.03–2.18) | 2.12 (2.04–2.21) | 0.97 | 0.68 |
| Monocyte Count (1000 per uL) | 0.53 (0.51–0.55) | 0.53 (0.51–0.55) | 0.55 (0.53–0.57) | 0.55 (0.53–0.57) | 0.02 | 0.01 |
| Neutrophil Count (1000 per uL) | 3.98 (3.82–4.15) | 3.98 (3.82–4.14) | 4.17 (3.99–4.34) | 4.18 (4.00–4.36) | 0.01 | <0.01 |
| Lymphocyte % | 32.1 (31.3–33.0) | 31.3 (30.4–32.3) | 31.1 (30.2–32.1) | 31.3 (30.3–32.2) | 0.02 | 0.01 |
| Monocyte % | 7.9 (7.6–8.2) | 7.9 (7.7–8.2) | 7.9 (7.7–8.2) | 7.9 (7.6–8.2) | 0.87 | 0.54 |
| Neutrophil % | 56.4 (55.4–57.4) | 57.0 (55.9–58.0) | 57.3 (56.2–58.4) | 57.1 (56.0–58.2) | 0.12 | 0.02 |
|
| ||||||
| BMI 25.0–29.9 | ||||||
|
| ||||||
| WBC Count (1000 per uL) | 7.20 (700–7.39) | 7.25 (7.07–7.42) | 7.26 (7.07–7.45) | 7.29 (7.10–7.49) | 0.30 | 0.05 |
| Lymphocyte Count (1000 per uL) | 2.19 (2.11–2.26) | 2.21 (2.13–2.28) | 2.17 (2.10–2.24) | 2.19 (2.12–2.26) | 0.96 | 0.89 |
| Monocyte Count (1000 per uL) | 0.55 (0.53–0.57) | 0.54 (0.52–0.56) | 0.54 (0.52–0.56) | 0.56 (0.54–0.58) | 0.44 | 0.73 |
| Neutrophil Count (1000 per uL) | 4.22 (4.08–4.36) | 4.25 (4.10–4.40) | 4.29 (4.13–4.45) | 4.32 (4.17–4.47) | 0.13 | 0.08 |
| Lymphocyte % | 31.4 (30.6–32.1) | 31.4 (30.6–32.3) | 30.9 (30.1–31.7) | 31.0 (30.2–31.7) | 0.24 | 0.07 |
| Monocyte % | 7.9 (7.6–8.1) | 7.7 (7.5–8.0) | 7.7 (7.5–8.0) | 7.8 (7.6–8.1) | 0.85 | 0.33 |
| Neutrophil % | 57.2 (56.3–58.0) | 57.2 (56.2–58.2) | 57.8 (56.9–58.8) | 57.6 (56.8–58.4) | 0.29 | 0.07 |
|
| ||||||
| BMI ≥ 30.0 | ||||||
|
| ||||||
| WBC Count (1000 per uL) | 7.86 (7.64–8.08) | 7.85 (7.65–8.05) | 7.95 (7.75–8.16) | 7.83 (7.64–8.02) | 0.71 | 0.95 |
| Lymphocyte Count (1000 per uL) | 2.32 (2.24–2.41) | 2.35 (2.27–2.42) | 2.36 (2.28–2.44) | 2.31 (2.22–2.39) | 0.59 | 0.89 |
| Monocyte Count (1000 per uL) | 0.58 (0.56–0.60) | 0.57 (0.56–0.59) | 0.58 (0.55–0.60) | 0.56 (0.54–0.58) | 0.03 | 0.06 |
| Neutrophil Count (1000 per uL) | 4.71 (4.54–4.87) | 4.67 (4.50–4.83) | 4.75 (4.60–4.91) | 4.69 (4.54–4.83) | 0.64 | 0.77 |
| Lymphocyte % | 30.2 (29.4–31.0) | 30.7 (29.9–31.5) | 30.4 (29.7–31.1) | 30.2 (29.4–31.1) | 0.94 | 0.78 |
| Monocyte % | 7.6 (7.4–7.8) | 7.5 (7.3–7.7) | 7.4 (7.2–7.6) | 7.4 (7.2–7.6) | 0.02 | <0.01 |
| Neutrophil % | 58.7 (57.8–59.7) | 58.1 (57.2–59.1) | 58.6 (57.6–59.5) | 58.7 (57.6–59.7) | 0.88 | 0.85 |
Adjustment: All leukocyte models adjusted for age, sex, race, education, marital status, smoking status, perceived health, self-reported diabetes, family member smoking status, infections in the past 30 days, waist circumference, and systolic blood pressure. DII quartile ranges: Quartile 1 = −5.96 to −0.87; Quartile 2 = −0.86 to 0.704; Quartile 3 = 0.71 to 1.97; Quartile 4 = 1.98 to 4.82. Quartile determinations were based on weighted values. Therefore, displayed sample size does not indicate equal quartiles; however, the weighted values were evenly distributed among quartiles.