Table 2.
Mean difference in health status outcomes over follow-up between patients with NSTEMI treated with initial invasive versus ischemia-guided management
| Seattle Angina Questionnaire | Short Form-12 | |||||
|---|---|---|---|---|---|---|
|
| ||||||
| Physical Limitation Estimate (95% CI) | Angina Frequency Estimate (95% CI) | Quality of Life Estimate (95% CI) | Summary Score Estimate (95% CI) | Physical Component Summary Estimate (95%CI) | Mental Component Summary Estimate (95%CI) | |
| Overall effect of invasive treatment | 3.7 (1.8, 5.5) p<0.001 | 1.4 (0.2, 2.7) p=0.02 | 1.5 (-0.1, 3.0) p=0.06 | 1.6 (0.4, 2.9) p=0.008 | 0.7 (-0.1, 1.5) p=0.07 | 0.7 (-0.0, 1.5) p=0.06 |
|
| ||||||
| Effect of treatment by month | ||||||
| Month 1 | 4.0 (1.5, 6.6) | 1.7 (-0.4, 3.8) | 1.3 (-1.5, 4.2) | 2.0 (-0.2, 4.1) | 0.9 (-0.1, 1.9) | 0.9 (-0.0, 1.9) |
| Month 6 | 3.5 (1.2, 5.7) | 0.5 (-1.6, 2.7) | 0.5 (-2.2, 3.3) | 1.1 (-1.1, 3.3) | 0.4 (-0.6, 1.4) | 0.9 (-0.1, 1.9) |
| Month 12 | 3.5 (1.4, 5.7) | -0.8 (-2.8, 1.3) | -1.0 (-3.7 1.7) | -1.0 (-3.1, 1.1) | 0.8 (-0.3, 1.8) | 0.3 (-0.6, 1.3) |
|
| ||||||
| Treatment*month interaction | p=0.70 | p=0.15 | p=0.04 | p<0.001 | p=0.83 | p=0.27 |
|
| ||||||
| Effect of invasive treatment by age group | ||||||
| <65 years | 3.4 (1.1, 5.6) | 1.7 (0.2, 3.3) | 1.8 (-0.3, 3.8) | 1.9 (0.3, 3.5) | 0.5 (-0.5, 1.5) | 1.1 (0.1, 2.0) |
| 65-74 years | 4.7 (1.0, 8.3) | 0.8 (-1.5, 3.2) | 2.2 (-1.0, 5.5) | 2.3 (-0.2, 4.9) | 1.6 (0.1, 3.2) | 0.3 (-1.1, 1.7) |
| 75-84 years | 3.4 (-1.6, 8.4) | 2.0 (-0.8, 4.8) | 1.3 (-2.6, 5.2) | 1.0 (-2.0, 4.0) | 1.0 (-0.8, 2.8) | 0.7 (-1.0, 2.4) |
| ≥85 years | 5.3 (-8.5, 19.1) | -2.6 (-8.3, 3.2) | -4.2 (-12.3, 3.9) | -2.5 (-8.8, 3.7) | -4.1 (-7.9, - 0.3) | -2.3 (-5.9, 1.3) |
|
| ||||||
| Treatment*age interaction | p=0.83 | p=0.21 | p=0.15 | p=0.15 | p=0.02 | p=0.09 |
Adjusted estimates derived using propensity-matched linear mixed effect models matched for baseline SAQ, demographic, socioeconomic, psychosocial, laboratory and medication information.