Table 1.

Quantitative assessments for selecting a reasonable h value given a certain T value include the cluster size and the maximum inter-parcel distance (D_max mm) for the largest fiber cluster (LFC) that formed with each setting. Note that given a certain T value (per column), the maximum possible parcel clique was a (T +1)-clique (see [68] for details) thus the maximum possible h was T (no two parcel cliques could share T +1 or more parcels). Therefore, no FCs formed when h > T. While a large h value (e.g. h = T ) tended to generate the most white-matter-constant FCs (a low D_max value), it was too strict when combining parcel cliques as FCs. Thus, it could overly limit the size of potential FCs that may be formed. For example, under h = T = 4, the LFC size was 6 (see Figure 5 for tract visualizations and comparisons across different h settings under T = 4), which meant that any FCs with sizes larger than 6 could not be identified. In this study, we set h = T – 2 (bold font per column) as a reasonable setting for a balance between a high WM anatomy consistency (a small D_max) and a high coverage of a local WM structure of fiber clusters (a large LFC size).

	T = 3		T = 4		T = 5		T = 6
	size	Dmax	size	Dmax	size	Dmax	size	Dmax
h = 1	18	66.2	64	90.4	433	142.3	604	144.7
h = 2	13	69.4	23	68.9	112	114.8	555	143.9
h = 3	5	48.7	8	59.0	15	51.5	56	94.0
h = 4	-	-	6	57.4	8	59.8	13	51.1
h = 5	-	-	-	-	6	58.9	7	59.8
h = 6	-	-	-	-	-	-	6	59.0