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. Author manuscript; available in PMC: 2019 Mar 15.
Published in final edited form as: Virus Res. 2018 Feb 3;248:13–23. doi: 10.1016/j.virusres.2018.01.015

Figure 4.

Figure 4

Passive transfer of neutralizing antibodies reduces viremia. PRRSV RNA quantification from serum by RT-qPCR for (A) genotype 2 MN184, and (B) genotype 1 SDEU, in PRRSV-naïve pigs administered neutralizing immune Ig (n= 12), non-neutralizing immune Ig (n= 12), PRRSV-negative or no Ig (combined control groups, n= 8). Difference in mean viremia between groups receiving neutralizing Ig or not (pooled non-neutralizing and negative Ig) was compared by one-tailed Mann Whitney test of area under the curve. AUC day 0–21 for MN184, p=0.0145. AUC day 0–21 for SDEU, p=0.03. Numbers above the X-axis are percent reduction at the indicated day after challenge. Dotted lines indicate the RT-PCR assay sensitivity limit for MN184 (A) or SDEU (B).