Brain edema at 72 h post-ICH. (A) Brain water content was increased in the ipsilateral basal ganglia in the s-ICH groups (10 μl and 30 μl) compared with that in the sham group (n=5 mice/group). (B) Brain water content was increased in the ipsilateral basal ganglia and cortex of the IVH groups (25 μl and 40 μl) compared with that in the sham group (n=5 mice/group). (C) Brain water content was increased in the ipsilateral cortex of the c-ICH groups (low- and high-dose collagenase groups) compared with that in the sham group (n=5 mice/group). (D) Brain water content was increased in the ipsilateral basal ganglia of the h-ICH group compared with that in the sham group (n=4 mice/group). All data are presented as mean ± SD; *P < 0.05, **P < 0.01 vs. Sham group. BG, basal ganglia; Cerebel, cerebellum; Cont, contralateral; CT, cortex; Ipsi, ipsilateral.