Figure 4.

AdNRTN Treatment of SMGs before IR Increases Salivary Flow Rates Similar to the Non-IR Group

Pilocarpine-stimulated whole saliva (in μL/15 min) was measured 60 days after IR. There was ∼60% reduction in saliva flow with IR compared with the non-IR group, and the control vector (AdC) did not increase saliva after IR. Non-IR SMGs were also treated with AdNRTN (10¹⁰ vp/g), and the AdNRTN (10⁸, 10⁹, and 10¹⁰ vp/g) treatment of IR SMGs improved saliva volume similar to the non-IR group. N = 8 mice, except non-IR AdNRTN¹⁰ vp/g, which had N = 4. Error bars represent the SEM. ANOVA with post hoc Dunnett’s test, ***p < 0.001 compared with non-IR.