Skip to main content
. 2018 Mar 12;9:87. doi: 10.3389/fendo.2018.00087

Figure 3.

Figure 3

Metabolic alterations of Recurrent (R) endometrial cancer differ between the histological subtypes. (A) R cases of type I histology are associated with reduced bile acid levels. Metabolites in bold were significantly altered (P < 0.05), whereas a trend (P < 0.10) was detected for underscored metabolites. Bile acids can be conjugated with glucose (G-), taurine (T-), glucuronic acid (-GA), or sulfate (-S). CA, cholic acid; DCA, deoxycholic acid; UDCA, ursodeoxycholic acid; IUDCA, isoursodeoxycholic acid; CDCA, chenodeoxycholic acid; LCA, lithocholic acid. (B) Normalized levels of the phosphorylated fibrinogen cleavage peptide ADpSGEGDFXAEGGGVR were higher in type I R cases. (C) Ceramide levels were significantly altered in type II R cases. Fold change is shown, and significant metabolites (P < 0.05) are identified by a black background, whereas a trend (P < 0.10) in metabolite differences is shown by gray shading. Cer, ceramide; -FA, fatty acid group; DEGS, dihydroceramide desaturase; CEGT, ceramide glucosyltransferase; GALT, galactosyltransferase; Gal, galactose; Glu, glucose.