Table 2.
Cluster size # voxels | Cluster p value | Voxel z value | Peak voxel MNI coordinates | Voxel region | |||
---|---|---|---|---|---|---|---|
Cocaine > neutral | |||||||
Cocaine usersb | 3,377 | <0.001 | >9.99 | −2 | 48 | −10 | L Medial orbital frontal cortex |
7.36 | 0 | 36 | −10 | R Medial orbital frontal cortex | |||
6.19 | −16 | 42 | 48 | L Superior frontal gyrus | |||
5.37 | −4 | 36 | 4 | L Anterior cingulate gyrus | |||
4.18 | −24 | 26 | 50 | L Middle frontal gyrus | |||
344 | 0.002 | 7.65 | 18 | −8 | −18 | R Parahippocampal gyrus | |
6.87 | 22 | −20 | −14 | R Hippocampus | |||
792 | <0.001 | 7.5 | 56 | −60 | −12 | R Inferior temporal gyrus | |
7.12 | 24 | −98 | −2 | R Inferior occipital gyrus | |||
6.57 | 46 | −54 | −20 | R Fusiform gyrus | |||
6.31 | 46 | −54 | −26 | R Cerebellum | |||
4.91 | 34 | −82 | 8 | R Middle occipital gyrus | |||
4.27 | 34 | −74 | −18 | R Fusiform gyrus | |||
60 | 0.002 | 6.45 | −4 | 6 | −6 | L Nucleus accumbensa | |
20 | 0.006 | 5.64 | 6 | 6 | −8 | R Nucleus accumbensa | |
46 | <0.001 | 7.70 | −20 | −8 | −16 | L amygdalaa | |
Controlsb | No significant clusters | ||||||
Neutral > cocaine | |||||||
Cocaine usersb | No significant clusters | ||||||
Controlsb | No significant clusters |
All results were p < 0.05, cluster level family-wise error corrected with an initial height threshold of p = 0.001 uncorrected.
aPeak value, corrected for the volume of the amygdala or nucleus accumbens, ppeak voxel < 0.05.
bOnly those regions that show a significant group by stimulus type interaction effect are reported.