Table 4.

Differences in amygdala connectivity during cue reactivity (cocaine versus neutral) and the relation to childhood trauma (CTQ), STAI-state, and its interaction.

	Cluster size # voxels	Clusterp value	Voxelz value	Peak voxel MNI coordinates			Voxel region
Left amygdala
Group × CTQ
Controls—positive correlationb	364	0.001	4.08	−24	16	0	L Putamen
			3.89	16	8	0	R Pallidum
			3.64	20	8	−6	R Putamen
Cocaine users—negative correlationb	177	0.039	4.43	−22	46	10	L Middle frontal gyrus
			3.53	−32	42	10	L Inferior frontal gyrus
	204	0.023	3.82	26	4	−10	R Putamen
			3.76	14	14	−2	R Caudate
Group × STAI-state	No significant clusters
Main effect STAI-state
Negative correlation	5,230	<0.001	5.01	16	0	50	R Superior frontal gyrus
			4.85	−48	−4	30	L Precentral gyrus
			4.6	−10	−14	54	L Supplementary motor area
			4.53	56	−12	20	R Postcentral gyrus
			4.36	−60	8	12	L Inferior frontal gyrus
			4.27	−54	−28	48	L Inferior parietal gyrus
			4.24	−50	−16	24	L Postcentral gyrus
	236	0.012	3.94	−50	−48	−6	L Inferior temporal gyrus
			3.65	−54	−46	−4	L Middle temporal gyrus
			3.48	−38	−48	−12	L Fusiform gyrus
	1,884	<0.001	4.26	14	46	18	R Anterior cingulate gyrus
			4.24	10	38	44	R Medial frontal gyrus
			3.93	−16	54	22	L Superior frontal gyrus
			3.93	−4	46	18	L Medial frontal gyrus
			3.81	−10	2	2	L Pallidum
	330	0.002	4.09	−32	28	24	L Inferior frontal gyrus
			3.54	−36	36	22	L Middle frontal gyrus
Positive correlation	No significant clusters
Group × CTQ × STAI-state	No significant clusters
Right amygdala
No significant main or interaction effects

All results were p < 0.05, cluster level family-wise error corrected with an initial height threshold of p = 0.001 uncorrected.

^bOnly those regions that show a significant group by stimulus type interaction effect are reported.