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. 2018 Mar 12;9:380. doi: 10.3389/fimmu.2018.00380

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Copyright © 2018 Ciabattini, Pettini, Fiorino, Lucchesi, Pastore, Brunetti, Santoro, Andersen, Bracci, Pozzi and Medaglini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antigen-specific IgG response. C57BL/6 mice were subcutaneously immunized as summarized in Figure 1. H56-specific IgG serum titers were analyzed on day 0, 12, 28, 31, and 38 following priming, by enzyme-linked immunosorbent assay. Antibody titers are expressed as the reciprocal of the highest serum dilution with an OD value ≥0.2 after subtraction of background value (diluent buffer). Values are reported as geometric mean titers (GMT) ± 95% CI of 8–10 mice per group from two independent experiments. Mann-Whitney test for multiple pairwise comparisons was used for assessing statistical difference between groups receiving the same booster and primed with H56 alone or H56 + CAF01 adjuvant, ^#P ≤ 0.05. Kruskal–Wallis test, followed by Dunn’s post test for multiple comparison, was used to assess statistical difference between all groups. *P ≤ 0.05.