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Epigenetic PPI inhibitors. (A–C) Chemical structures of the inhibitors mentioned in this review. (D–F) The detailed interactions patterns of EZH2-EED (PDB code: 2QXV), WDR5-MLL1 (PDB code: 3EG6), and Menin-MLL1 (PDB code: 4GQ6). EED, WDR5, and Menin are represented in surface contours. The side chains of key residues involved in hydrophobic interactions are depicted in red while the ones involved in polar interactions are depicted in yellow.
