Table 5.

HRs and 95% CI for two consecutive changes of DM treatment by PCa diagnosis and PCa treatments

	Multivariate analysis*
		HR	95% CI
PCa diagnosis	No PCa	1.00	(Ref)
	PCa	1.75	1.38 to 2.22
PCa treatment	No PCa	1.00	(Ref)
	No ADT	1.40	1.03 to 1.92
	AA	0.91	0.29 to 2.82
	GnRH	3.08	2.14 to 4.44
PCa diagnosis in relation to prior change in T2DM treatment	No PCa	1.00	(Ref)
	PCa prior to one change	1.09	0.78 to 1.54
	PCa after one change	3.59	2.61 to 4.93

*Multivariate analysis with age as time scale and adjusted for education status and initial diabetes treatment.

AA, antiandrogen; ADT, androgen deprivation therapy; GnRH, gonadotropin-releasing hormone agonist; PCa, prostate cancer; T2DM, type 2 diabetes mellitus.