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. 2018 Jan 18;10(2):375–389. doi: 10.1016/j.stemcr.2017.12.018

Figure 2.

Figure 2

Characterization of Stress Granules in WT and P525L FUS-eGFP SL iPSCs

(A) Confocal micrographs demonstrating that iPSCs form FUS-eGFP SGs that co-localize with eIF3. Scale bar, 20 μm.

(B–G) Quantification of SGs positive for FUS-eGFP in WT and P525L iPSCs (B). Error bars indicate SD. Histograms are shown for the frequency of WT and P525L FUS-eGFP SG area (C) and mean intensity (D). In contrast to SGs, FUS-eGFP puncta do not co-localize with eIF3-positive structures (E and F) and display smaller size (G). Data represent results from three independent experiments.