Table 1.
Thalamic HFS-Evoked BOLD Signals and Tic Reduction Correlation (ROI-level).
| Regions | Volume mm3 |
Coordinates (x, y, z) |
Max t-Score |
Correlation coefficient |
|---|---|---|---|---|
| Cerebellar | ||||
| IL cerebellum | 1104 | −15, +61, −16 | +4.91 | +0.42 |
| CL cerebellum | 6072 | +9, +57, −22 | +6.25 | +0.63* |
| Cortices and gyri | ||||
| IL/CL cuneus/precuneus/isthmus cingulate cortices | 4584 | +1, +71, +20 | +7.19 | −0.48 |
| IL/CL caudal/rostral anterior cingulate cortices | 2920 | −9, −31, +6 | −4.44 | +0.08 |
| IL/CL anterior cingulate/medial orbitofrontal cortices | 1048 | −11, −51, +4 | −2.64 | +0.66* |
| IL lateral orbitofrontal cortex | 744 | −41, −17, −12 | −4.04 | +0.86* |
| CL lateral orbitofrontal cortex | 1696 | −43, −37, −6 | −2.32 | +0.18 |
| IL medial frontal gyrus | 1208 | −7, −25, +44 | −3.13 | −0.32 |
| IL insula | 824 | −41, −15, −4 | −4.32 | +0.65* |
| IL lateral occipital/lingual/pericalcarine gyri | 2640 | −9, +69, +8 | +4.94 | +0.43 |
| CL lateral occipital/lingual/pericalcarine gyri | 2448 | +17, +65, −12 | +6.29 | +0.58* |
| IL inferior parietal cortex | 312 | −45, +55, +18 | +2.85 | +0.22 |
| CL inferior parietal cortex | 2160 | +39, +53, +26 | +2.62 | −0.26 |
| CL superior parietal cortex | 304 | +11, +67, +50 | +4.85 | +0.30 |
| IL sensorimotor cortex | 9696 | −49, +11, +28 | +4.26 | +0.29 |
| IL superior/medial/inferior temporal cortices | 1496 | −39, −5, −14 | −4.70 | +0.79* |
| CL superior temporal/pars orbitalis cortices | 1208 | +39, −21, −12 | −2.94 | +0.74* |
| IL inferior temporal gyrus | 1488 | −41, +7, −22 | +3.36 | −0.86* |
| Subcortical structures | ||||
| IL caudate/pallidum/putamen | 3384 | −15, +1, +22 | −5.53 | −0.23 |
| CL caudate/pallidum/putamen | 1992 | +19, +7, +16 | −4.77 | −0.11 |
| IL/CL thalamus | 3480 | −13, +23, +8 | +9.94 | +0.63* |
| IL amygdala/accumbens area | 392 | −29, +9, −10 | −6.34 | −0.18 |
| CL amygdala/accumbens area | 1272 | +5, −5, −14 | −3.74 | +0.80* |
| Brain stem | 2088 | −1, +21, −18 | +6.97 | −0.18 |
Regions showing significant correlations in bold (* FWE-corrected p < 0.05). Abbreviations: BOLD, blood-oxygen-level dependent; CL, contralateral to the injection/stimulation site; HFS, high frequency stimulation; IL, ipsilateral to the injection/stimulation site; ROI, region of interest.