Fig. 2.

The first component of multivariate whole-brain analysis of functional connectivity correlates with symptom severity. (A) Voxel salience map a₁ with effect size reported as bootstrap ratios. (B) Concussed athlete “subject scores”, reflecting how strongly they express the functional pattern depicted in panel A, are plotted against ranked symptom severity scores. Horizontal lines show the mean (solid line), 90% CI (dashed lines) and 95% CI (dotted lines) of control athletes subject scores at baseline testing. (C) Functional connectivity plots for the top 10% of voxels with highest bootstrap ratios in panel A, for representative concussed athletes with low symptom scores (L1, L2, L3) and with high symptom scores (H1, H2, H3), along with the mean connectivity map averaged over all controls.