Table 3. Summary of odds ratios (95% CI) in the analysis of the association between the LPL N291S and D9N polymorphisms and CAD susceptibility.
| Genetic model | Overall and subgroups | N | Test of association | Test of heterogeneity | |||
|---|---|---|---|---|---|---|---|
| OR | 95% CI | P-value | P Heterogeneity | I2 (%) | |||
| N291S | |||||||
| GG + GA vs. AA | Overall | 11 | 1.11 | 0.97,1.28 | 0.130 | 0.420 | 3% |
| Asians | 1 | 1.54 | 0.89,2.68 | 0.120 | N/A | N/A | |
| Caucasians | 8 | 1.10 | 0.95,1.27 | 0.210 | 0.300 | 16% | |
| Large sample | 7 | 1.13 | 0.98,1.30 | 0.100 | 0.320 | 15% | |
| Small sample | 4 | 0.96 | 0.57,1.60 | 0.860 | 0.430 | 0% | |
| D9N | |||||||
| AA + GA vs. GG | Overall | 8 | 1.46 | 1.14,1.87 | 0.002 | 0.360 | 9% |
| Asians | 1 | 0.41 | 0.05,3.73 | 0.430 | N/A | N/A | |
| Caucasians | 4 | 1.47 | 1.00,2.14 | 0.050 | 0.200 | 36% | |
| Large sample | 4 | 1.49 | 1.03,2.15 | 0.040 | 0.180 | 38% | |
| Small sample | 4 | 0.94 | 0.42,2.10 | 0.890 | 0.670 | 0% | |
Abbreviations: CAD, coronary artery disease; CI, confidence interval; LPL, lipoprotein lipase; N, number of studies; N/A, not applicable; OR, odds ratio; P-Value, P value for association; P Heterogeneity, P value for heterogeneity.