Table 1.

List of current clinical trials registered as recruiting on the ClinicalTrials.gov and NHS sites in 2017.

Study	Principal Investigator	Sites	Phase	Status	Study Design	Population	Drug	Intervention Method
A Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter, Phase 3 Study of OTO-104 Given as a Single Intratympanic Injection in Subjects With Unilateral Menière's Disease	Carl LeBel, Ph.D.	Multiple sites in USA, and Europe	Phase 3	Recruiting	Randomized	Adults with Unilateral Menière's disease by 1995 AAO-HNS criteria	OTO-104 (dexamethasone sustained-release formulation) vs Placebo	IT Injection
Lamotrigine for Menière's Disease: a Double-blind, Placebo-controlled Pilot Study	Lixin Zhang, M.D., Ph.D.	Dent Neuroscience Research Center, Amherst NY	Phase 3	Recruiting	Randomized	Adults with Unilateral Menière's disease by 1995 AAO-HNS criteria	Lamotrigine vs Placebo	Oral
Reduction of Plasma Vasopressin Level in Patients With Menière's Disease	Tadashi Kitahara, M.D., Ph.D.	Osaka University, Suita-city, Osaka, Japan	N/A	Recruiting	Randomized	Patients diagnosed as Menière's patients according to the 1995 AAO-HNS criteria	None	Lifestyle
Phase 1b Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of SPI-1005 in Menière's Disease	Jonathan Kil, M.D.	Multiple sites in USA (CA, NY, SC, WA)	Phase 1	Invitation	Randomized	By invitation, Adults with Unilateral Menière's disease by 1995 AAO-HNS criteria	SPI-1005 (small molecule mimics glutathione peroxidase) vs Placebo	Oral