Fig. 4.
Serum MPs isolated from sham and TBI mice alter coagulation. MPs were isolated from whole blood from sham and TBI mice 24 h after injury. MP concentrations were normalized to 3.0 × 108 MPs/mL in 30 μL sterile saline were then added to whole blood from sham and TBI mice and thromboelastometry performed. (A) FIBTEMMCF and (B) platelet contribution to clot formation after saline, sham MPs, and TBI MPs are added to sham whole blood. (C) FIBTEMMCF and (D) platelet contribution to clot formation after saline, sham MPs, and TBI MPs are added to TBI whole blood. Data are expressed as the mean ± standard error of the mean. Samples sizes are 8–10 for each group. *P <0.01 based on one-way analysis of variance with Tukey post hoc test compared with sham.