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. 2018 Feb 5;293(11):3981–3988. doi: 10.1074/jbc.RA117.000885

Figure 4.

Figure 4.

MAR1 administration attenuates hepatic steatosis and both AMPK phosphorylation and SERCA2b expression. A, H&E and Oil Red-O staining on liver sections of experimental animals: ND, HFD, and HFD plus MAR1 (HFD+MAR1). TG accumulation was quantitated by a TG assay kit. Western blot analysis (B) and quantitative RT-PCR (C) of lipogenic markers are shown. ER stress markers' phosphorylation and expression and quantitative RT-PCR of spliced Xbp-1 mRNA expression (D) in liver of experimental mice are shown. Western blot analysis of AMPK phosphorylation and SERCA2 expression and quantitative RT-PCR of Serca2b mRNA expression (E) in livers of experimental mice are shown. Means ± S.D. were obtained from five individual animals. One-way ANOVA with Tukey post hoc was performed. ***, p < 0.001, **, p < 0.01, and *, p < 0.05 when compared with ND treatment. !!!, p < 0.001, !!, p < 0.01, and !, p < 0.05 when compared with the HFD.