Table 2.
Test Phase Using Single Assays for UC (n = 21) vs CC (n = 12)
| miRNA | P * | FDR† | Fold Change‡ | AUC (95% CI) | Sensitivity (95% CI), % | Specificity (95% CI), % | Accuracy (95% CI), % |
|---|---|---|---|---|---|---|---|
| let-7d | 0.361 | 0.615 | 1.654 | 0.67 (0.53–0.81) | 61.9 (46.8–75) | 75.0 (54.8–88.3) | 66.7 (54.6–76.9) |
| miR-101 | 0.541 | 0.659 | 1.220 | 0.63 (0.50–0.76) | 52.4 (37.7–66.6) | 79.2 (59.1–91.2) | 62.1 (50.0–72.9) |
| miR-22 | 0.659 | 0.659 | 0.856 | 0.44 (0.30–0.58) | 73.8 (58.8–84.8) | 100 (83.7–100) | 47.0 (35.4–58.8) |
| miR-576-3p | 0.596 | 0.659 | 1.351 | 0.66 (0.52–0.80) | 64.3 (49.1–77.1) | 79.2 (59.1–91.2) | 69.7 (57.7–79.5) |
| miR-598 | 0.013 | 0.054 | 1.831 | 0.67 (0.54–0.80) | 69.0 (53.9–81) | 62.5 (42.6–78.9) | 66.7 (54.6–76.9) |
| miR-642 | 0.005 | 0.040 | 4.327 | 0.69 (0.56–0.82) | 73.8 (58.8–84.8) | 66.7 (46.6–82.2) | 71.2 (59.3–80.8) |
| miR-744 | 0.172 | 0.458 | 1.598 | 0.61 (0.48–0.75) | 35.7 (22.9–50.9) | 95.8 (78.1–100) | 57.6 (45.6–68.8) |
Each reaction was performed in duplicate. miRNAs that were found to be significantly different are depicted in boldface.
*Student t test.
†False discovery rate, α = 0.05.
‡Comparative ΔCT method (2-ΔΔCT).