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. 2018 Feb 8;15(4):5694–5702. doi: 10.3892/ol.2018.8000

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Copyright: © Wang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — CAFs induce tumorigenesis, lung metastasis and the epithelial-mesenchymal transition process in vivo. (A) The tumor weight in the CAFs and NFs group. (B) The tumor volume in the CAFs and NFs group. (C) Vimentin, Snail, CD44 and CD24 macroscopic images of immunohistochemistry in the CAFs and NFs group at magnification, ×400. The arrows indicated the areas of lung metastasis. Data are presented the mean ± standard error of the mean (n=10). CAFs, cancer-associated fibroblasts; NFs, normal fibroblasts; Snail, zinc finger protein SNAI1; CD, cluster of differentiation.