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. 2018 Feb 14;15(4):5751–5759. doi: 10.3892/ol.2018.8055

Figure 2.

Figure 2.

In vitro expression of EGFRvIII, EGFR, AKT-1, MMP-2, MMP-9 and Ku70. (A) Levels of expression of EGFRvIII, EGFR, AKT-1, MMP-2, MMP-9 and Ku70 proteins in vitro in U87-EGFRvIII cell lines treated with negative control, 6 Gy radiation, 12 Gy radiation, and combined treatment of 6 Gy radiosurgery and temozolomide. (B) Schematic diagram illustrating the combined treatment of radiosurgery and temozolomide. EGFR, epidermal growth factor receptor; EGFRvIII, EGFR variant III; AKT-1, RAC-α serine/threonine-protein kinase; MMP-2, matrix metalloproteinase 2; MMP-9; Ku70, X-ray repair cross-complementing protein 6; GMB, glioblastoma multiforme; DMSO, dimethyl sulphoxide; TMZ, temozolomide.