Figure 2.

Mean change from baseline in the common carotid intima-media thickness (a) and in the calcified coronary atherosclerotic plaques (b) in the TEAAM trial (adapted from Basaria et al.47). Error bars represent 95% confidence interval. The model-estimated between-group difference represents the change from baseline to the end-of-treatment in coronary artery calcium scores in participants who completed the intervention. The model controls stratification by age group and study center, using mixed-effects regression model in which subjects were nested within study center (random effect). Age-group, time-in-treatment, and treatment-by-time interaction were included as fixed effects, with the latter quantifying the estimated treatment effect. The missing data were accommodated using multiple imputations in which missing outcomes values were estimated using predictive mean matching. TEAAM: Testosterone's Effect on Atherosclerosis Progression in Aging Men.