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. 2018 Feb 20;14(53):44–52. doi: 10.4103/pm.pm_483_16

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Copyright: © 2018 Pharmacognosy Magazine

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Effect of RE and metoprolol on the endothelial nitric oxide synthase expression in thoracic aortic and small vessels of heart and kidney. (a) Representative photomicrograph of the endothelial nitric oxide synthase expression in thoracic aortic by immunohistochemistry (×400); (b) Representative photomicrograph of the endothelial nitric oxide synthase expression in small vessels of heart by immunohistochemistry (×400); (c) Representative photomicrograph of the endothelial nitric oxide synthase expression in small vessels of kidney by immunohistochemistry (×400). eNOS: Endothelial nitric oxide synthase; RE: Paeoniflorin enriched extract from Radix Paeoniae alba; NC: Normal control; MC: Model control; MP-H: Metoprolol high dose (20 mg/kg, p.o.); MP-L: Metoprolol low dose (6 mg/kg, p.o.); RE-H: RE high dose (90 mg/kg, p.o.); RE-L: RE low dose (30 mg/kg, p.o.); MP + RE: MP combined with RE (6 mg/kg + 30 mg/kg, p.o.)