Table 2.
eQTLs and AEI in AF GWAS loci.
| AF GWAS locus | Nominal gene attribution | AF GWAS SNP* | Top eQTL Gene | Top eQTL Symbol | eQTL Beta† | eQTL p-value | eQTL q-value | GWAS SNP evidence AEI (p-value) | AEI indicator SNP |
|---|---|---|---|---|---|---|---|---|---|
| 1q21.3 | KCNN3, PMVK | rs6666258 | ENSG00000173207 | CKS1B | -0.05 | 4.53E-03 | 5.87E-02 | NA‡ | NA |
| 1q24.2 | METTL11B | rs12044963 | ENSG00000231437 | RP11-88H9.2 | 0.17 | 1.51E-02 | 7.36E-01 | NA | NA |
| 1q24.2 | PRRX1 | rs3903239 | ENSG00000116132 | PRRX1 | -0.16 | 2.86E-05 | 9.33E-04 | NA | NA |
| 2p13.3 | ANXA4, GMCL1 | rs3771537 | ENSG00000124380 | SNRNP27 | -0.05 | 6.22E-06 | 3.11E-04 | NA | NA |
| 2p14 | CEP68 | rs2540953 | ENSG00000011523 | CEP68 | -0.10 | 4.98E-13 | 7.13E-11 | NA | NA |
| 2q31.2 | TTN, TTN-AS1 | rs2288327 | ENSG00000079150 | FKBP7 | 0.10 | 2.40E-06 | 1.33E-04 | NA | NA |
| 3p25.1 | CAND2 | rs4642101 | ENSG00000144712 | CAND2 | -0.04 | 8.10E-03 | 8.85E-02 | NA | NA |
| 4q25 | PITX2 | rs6817105 | ENSG00000250103 | PANCR | 0.02 | 7.44E-01 | 7.76E-01 | NA | NA |
| 5q22.3 | KCNN2 | rs337711 | ENSG00000080709 | KCNN2 | -0.08 | 1.55E-03 | 3.35E-02 | NA | NA |
| 5q31.2 | WNT8A | rs2040862 | ENSG00000031003 | FAM13B | -0.24 | 6.91E-30 | 4.83E-27 | 2.10E-05 | rs3777118 |
| 6q22.31 | SLC35F1, PLN | rs4946333 | ENSG00000111860 | CEP85L | -0.04 | 7.70E-02 | 4.19E-01 | NA | NA |
| 6q22.31 | GJA1 | rs12664873§ | ENSG00000152661 | GJA1 | -0.07 | 1.62E-02 | ND§ | NA | NA |
| 7q31.2 | CAV1 | rs3807989 | ENSG00000105974 | CAV1 | -0.10 | 1.55E-07 | 8.96E-06 | 1.98E-9 | rs1049337 |
| 8p22 | ASAH1, PCM1 | rs7508 | ENSG00000104763 | ASAH1 | 0.08 | 1.69E-07 | 1.22E-05 | 5.60E-08 | rs3810 |
| 9q22.32 | C9ORF3 | rs10821415 | ENSG00000158169 | FANCC | 0.04 | 1.84E-02 | 1.54E-01 | NA | NA |
| 10q22.2 | SYNPO2L | rs10824026 | ENSG00000177791 | MYOZ1 | -1.87 | 2.90E-38 | 3.65E-35 | NA | NA |
| 10q24.33 | NEURL1 | rs6584555 | ENSG00000173915 | USMG5 | 0.03 | 4.13E-02 | 2.52E-01 | NA | NA |
| 10q24.33 | SH3PXD2A | rs2047036 | ENSG00000107957 | SH3PXD2A | -0.01 | 3.80E-01 | 6.53E-01 | NA | NA |
| 11q24 | KCNJ5 | rs75190942 | ENSG00000174370 | C11orf45 | 0.29 | 1.59E-06 | 9.20E-05 | NA | NA |
| 12q24.21 | TBX5 | rs10507248 | ENSG00000089225 | TBX5 | 0.07 | 4.87E-04 | 1.03E-02 | NA | NA |
| 14q23.2 | SYNE2 | rs1152591 | ENSG00000054654 | SYNE2 | -0.17 | 2.31E-19 | 6.73E-17 | 3.02E-09 | rs35648226 |
| 15q24.1 | HCN4 | rs7164883 | ENSG00000183324 | REC114 | -0.15 | 6.71E-02 | 3.27E-01 | NA | NA |
| 16q22.3 | ZFHX3 | rs2106261 | ENSG00000259768 | antisense-ZFHX3 | -0.09 | 1.57E-01 | 4.80E-01 | NA | NA |