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. 2018 Feb 12;8(7):1808–1823. doi: 10.7150/thno.23177

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Conditional depletion of PHGDH suppresses the adaptive resistance to erlotinib treatment in vivo. (A) Tumor growth curve of subcutaneous HCC827 pT-shPHGDH#4 xenografts in nude mice. The xenografts harboring mice were gavaged with dosage escalation of erlotinib, from 5 to 50 mpk opd, or drinked doxycycline (2 mg/mL) containing water, or combination of erlotinib and doxycycline. (B) Weight of resected HCC827 pT-shPHGDH#4 tumors as indicated. (C) HE and IHC staining of PHGDH. (D) Tumor growth curve of subcutaneous PC9 pT-shPHGDH#4 xenografts in nude mice. Nude mice bearing PC9 pT-shPHGDH#4 tumors in the flank were treated as indicated. (E) The weight of PC9 pT-shPHGDH#4 tumor mass. Mean tumor volume ± SEM are shown in 5-6 mice per group. *, p < 0.05; **, p < 0.01; ***, p < 0.001, ****, p < 0.0001.