Figure 5.

Tungsten sulfide (WS₂) quantum dots (QDs) as multifunctional nanotheranostic agents for in vivo dual-modal image-guided photothermal/radiotherapy synergistic therapy. (A) Schematic illustration of WS₂ QDs for dual-mode computed tomography (CT)/photoacoustic (PA) imaging and photothermal therapy (PTT)/radiation therapy (RT) synergistic therapy. (B) Atomic force microscopy (AFM) topography images of the as-prepared WS₂ QDs. (C) Temperature change of WS₂ QD solution at a concentration of 100 ppm over four laser on/off cycles. (D) PA images of BEL-7402 human hepatocellular carcinoma-bearing mice before and after the intravenous injection of WS₂ QDs. (E) CT images of tumor before and after the intravenous injection of WS₂ QDs. (F) Representative images of different groups of BEL-7402 human hepatocellular carcinoma-bearing mice after different administrations at the end of PTT and RT. Reproduced with permission from reference ¹⁹⁴, copyright 2015 American Chemical Society.