Table 3.

Clinical trials investigating NBTXR3^a crystalline nanoparticle-RT combination (records in https://clinicaltrials.gov/)

ClinicalTrials.gov Identifier	Start year	Phase	Indication	Number of patients	Country & region	Status
NCT01433068	2011	I	Adult soft tissue sarcoma	22	France	Completed
NCT01946867	2013	I	Head and neck cancer	48	France, Spain	Recruiting
NCT02379845	2015	II/III	Adult soft tissue sarcoma	180	Australia, Belgium, France, Germany, Hong Kong, Hungary, Italy, Norway, Philippines, Poland, Romania, South Africa, Spain	Recruiting
NCT02465593	2015	I/II	Rectal cancer	42	Taiwan	Recruiting
NCT02721056	2015	I/II	Hepatocellular carcinoma; liver cancer	200	France	Recruiting
NCT02805894	2016	I/II	Prostate cancer	96	United States	Recruiting
NCT02901483	2016	I/II	Head and neck squamous cell carcinoma	42	Taiwan	Recruiting

^aNBTXR3, 50-nm-sized crystalline HfO₂ nanoparticles bearing a negative surface charge.