Figure 7.
Ultrasound molecular imaging assessment of atorvastatin efficacy. (A) Representative H&E images of ascending aorta sections from ApoE-/- mice fed atorvastatin or placebo in their daily hypercholesterolemic diets for 8 weeks. Scale bar = 50 μm. (B) Quantitative analysis of intima-medial thickness, with reduced intima-medial thickness in the atorvastatin-treated A-HD mice. *: P < 0.05. (C) Representative color-coded images of ascending aorta generated from adherent MBVIS or MBIgG. Scale bar = 1 mm. (D) Quantitative analysis of signal intensities from (C). A-HD mice were raised with atorvastatin or placebo added into their daily hypercholesterolemic diet for 8 weeks. *: P < 0.05.