Table 1.
Pharmacokinetic parameters of PTX prodrugs compared with free PTX. Results represent mean ± S.E. (n = 5)
| Parameter | Units | PTX | FA-PTX | PTX-EB | FA-PTX-EB |
|---|---|---|---|---|---|
| Cmax | ng/mL | 7854 ± 403 | 8034 ± 512 | 8396 ± 422 | 9132 ± 412 |
| AUC | ng.h/mL | 7630 ± 114 | 15657 ± 368 | 59570 ± 428 | 134922 ± 624 |
| t1/2ɑ | h | 0.201 ± 0.01 | 0.129 ± 0. 01 | 0.068 ± 0.001 | 0.033 ± 0.001 |
| t1/2β | h | 2.19 ± 0.32 | 3.82 ± 0.53 | 4.41 ± 0.48 | 7.51 ± 0.68 |
| CL | mL/h/kg | 1.31 ± 0.53 | 1.08 ± 0.46 | 0.58 ± 0.32 | 0.29 ± 0.08 |
Pharmacokinetic parameters were calculated using a two-compartment model. Values are the calculated pharmacokinetic parameter ± the standard error of the estimated single model-dependent calculations