Table 3.

Pharmacokinetic parameters of PTX prodrugs compared with free PTX. Results represent mean ± S.E. (n = 5)

Parameter	Units	PTX	FA-PTX	PTX-EB	FA-PTX-EB
Cmax	ng/mL	5769 ± 712	9181 ± 639	3917 ± 233	4285 ± 405
AUC	ng.h/mL	46821 ± 1025	234286 ± 2204	8659 ± 1062	118971 ± 1256
t1/2	h	2.15 ± 0.62	6.82 ± 0.53	1.41 ± 0.48	3.29 ± 0.56
CL	mL/min	28.57 ± 3.03	10.21 ± 4.25	15.07 ± 2.02	7.17 ± 2.09

Kidney tissue pharmacokinetics were calculated using non-compartmental analysis