Table 4.

Pharmacokinetic parameters of PTX prodrugs compared with free PTX. Results represent mean ± S.E. (n=5)

Parameter	Units	PTX	FA-PTX	PTX-EB	FA-PTX-EB
Cmax	ng/mL	3938 ± 304	7108 ± 611	6503 ± 455	12948 ± 1766
AUC	ng.h/mL	21511 ± 1244	131053 ± 5462	31825 ± 1102	391016 ± 1232
t1/2	h	6.19 ± 0.32	44.21 ± 2.53	34.41 ± 3.48	124.51 ± 4.68
CL	mL/h/kg	13.11 ± 2.14	16.88 ± 5.09	22.23 ± 4.32	29.86 ± 2.98

Tumor tissue pharmacokinetics were calculated using non-compartmental analysis