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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Thorax. 2017 Jan 12;72(11):971–980. doi: 10.1136/thoraxjnl-2016-208571

Figure 3.

Figure 3

Aspirin reduces neutrophil proteases in the bronchoalveolar lavage (BAL) fluid of healthy volunteers who have inhaled lipopolysaccharide (LPS). BAL as in figure 2A was analysed for neutrophil granular enzymes. (a) Aspirin significantly reduced BAL MMP-8 (difference in median 2.2 ng/mL, 95% CIs 0.15 to 4.45; *p=0.04 for aspirin (n=20) vs. placebo (n=13)). (B) Aspirin significantly reduced BAL MMP-9 (difference in medians 14.2 ng/mL, 95% CIs 1.0 to 29.8; *p=0.04 for aspirin (n=20) vs. placebo (n=13)). (C) Aspirin did not significantly reduce MPO (n=20) versus control (n=13) (difference in median 12.4 ng/mL, 95% CIs −6.6 to 52.6; p=0.19). (D) Aspirin (n=20) did not statistically significantly reduce BAL neutrophil elastase compared with placebo (n=13) (median difference 4.5 ng/mL, 95% CIs −3.0 to 26.4; p=0.30).