Table 4.

The effect of high-dose versus low-dose aspirin on bronchoalveolar lavage (BAL) and plasma biomarkers

	Aspirin 75 mg	Aspirin 1200 mg
BAL
Neutrophils (×105/mL)	1.6 (1.3–2.8)	1.5 (1.2–1.7)
MMP-8 (ng/mL)	3.4 (2.3–4.8)	2.6 (1.9–4.0)
MMP-9 (ng/mL)	33.7 (27.1–50.1)	33.7 (16.1–44.4)
MPO (ng/mL)	38.6 (29.2–53.3)	25.2 (17.5–34.6)
NE (ng/mL)	10.6 (6.0–15.6)	21.1 (11.1–36.1)
TNFα (pg/mL)	77 (51–100)	90 (49–141)
IL-6 (pg/mL)	563 (368–880)	782 (284–901)
IL-8 (pg/mL)	308 (264–431)	397 (269–515)
MCP-1 (pg/mL)	497 (385–967)	502 (289–924)
IL-1β (pg/mL)	46 (30–66)	30 (16–38)
IL-1Ra (pg/mL)	3000 (2413–4182)	2266 (1700–3682)
TIMP-1 (pg/mL)	2155 (1431–3783)	2243 (1275–3789)
TIMP-2 (pg/mL)	566 (495–912)	574 (224–805)
SP-D (pg/mL)	27810 (23 356–38 705)	35242 (23 800–41 848)
CRP (pg/mL)	449 (97–943)	237 (116–867)
Plasma
CRP (mg/L)	40 (33–61)	32 (25–63)

Data are median (IQR).

IL, interleukin; TNFα, tumour necrosis factor α.