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. Author manuscript; available in PMC: 2018 Mar 19.
Published in final edited form as: J Harmon Res Med Health Sci. 2016 Dec;3(4):247–264.

Table 3.

Representative H3 amino acid changes and genetic characterization of DRC isolates compared to A/Texas/50/2012 vaccine virus

HA Group Strain Name Amino Acid Annotation and Numbering after Signal Peptidea Number of
AA Differences
3 4 38 53 56 62 78 83 94 122 124 128 138 140 142 144 145 157 159 160 168 171 173 186 188 192 198 199 214 219 225 261 262 311 326 347 402 489 510 529
3C.1 A/Texas/50/2012 (2013-15 Vaccine) L P N D H E G K Y N S N A I R N N L F K M N Q V D I P S I F N R S Q K V V D G V
3C.2a A/Congo/2471/2014Dec I P/T T S S Y T K G S S D H N 14
A/Congo/2538/2014Dec I T S S Y K G S S D H N 12
A/Congo/2461/2014Dec I T S S Y T K G S S D H I N 14
A/Congo/2544/2014Dec I T S S Y T K G E S S D H N 14
A/Congo/2458/2014Dec I T S S Y T K G S S D H N 13
A/Congo/2495/2014Dec I T S S Y T K G S S D H N 13
A/Algiers/249/2014Dec I T S S Y T G S S D H N 12
A/Mauritius/853/2014Oct I T S S Y T G S S D H N I 13
A/Tanzania/594/2014Dec I T S S Y T V G S S D H N 13
A/Tanzania/3565/2014Nov I T S S Y T V G S S D H N 13
A/Mauritius/912/2014Nov T S S Y T G S S D Q H N 12
3C.3 A/Congo/2611/2014Dec S N A G S G S S E 9
A/Congo/2557/2014Dec I N N A G S G V S S 10
A/Zambia/04-303/2014Nov N A G S H G S S 8
A/Zambia/04-288/2014Dec N A G S H G S S 8
A/Zambia/06-024/2014Sep N A G S G S S 7
A/Kenya/127/2014Aug D A R G S G S I/L S 9
3C.3a A/Switzerland/9715293/2013 (2015 Vaccine) A S G S S G S S D R 10
A/Madagascar/3069/2014Oct H/Y A S G S S G S S D R 11
A/Algiers/08/2014Oct A S G S S G S D R 9
A/Tanzania/1906/2014Dec H/Y E/K H A S G S S G S S D R 13
A/Tanzania/3580/2014Nov A S G S S G S S D N R 11
A/Ethiopia/1147/2014Oct H A S G S S G S S D 10
A/Ethiopia/1153/2014Nov H A S G S S G S S D 10
A/Ghana/DILI-14-1014/2014Nov A S G S S G S D N 9
A/Ghana/DILI-14-1152/2014Dec A S G S S G S D N 9
A/Dakar/30/2014Oct A S G S S G S S D 9
3C.3b A/Egypt/4870/2014Nov K R D A G S S G S S Q K 12
A

Only amino acid differences found in virus isolates from Africa are shown