Table 4.

Representative H1pdm09 amino acid changes and genetic characterization of DRC isolates compared to A/California/07/2009 vaccine virus

HA Group	Strain Name	Amino Acid Annotation and Numbering after Signal Peptidea																										Total Number of AA Differences
		30	48	83	84	97	116	163	183	185	186	195	203	222	223	234	256	257	283	321	361	374	379	401	451	496	499
	A/California/07/2009Vaccine	V	A	P	S	D	I	K	S	S	A	A	S	D/G	Q/R	V	A	M	K	I	Y	E	V	E	S	N	E
6B	A/Congo/2278/2014Nov			S	N	N		Q		T		V	T	D	Q		T		E	V		K			N	T	K	16
	A/Congo/2275/2014Nov			F		N		Q		T			T	D	Q		T		E	V		K		D			K	13
	A/Ethiopia/63/2014Nov			S		N		Q		T			T	D	Q		T		E	A/V		K			N		K	14
	A/Ethiopia/66/2014Nov		P	S		N		Q		T			T	D	Q		T		E	V	F/Y	K			N		K	15
	A/Ethiopia/1149/2014Oct		P	S		N		Q		T			T	D	Q		T		E	V		K			N		K	14
	A/Egypt/4372/2014Oct			S		N		Q	P/S	T			T	D	Q		T		E	V		K			N		K	14
	A/Egypt/4758/2014Oct			S		N		Q		T			T		Q		T		E	V		K	A		N		K	13
	A/South Africa/3626/2013Jun			S		N		Q		T			T	D	Q		T		E	V		K			N		K	15
6C	A/Ghana/FS-14-1022/2014Nov			S		N	M			T	T		T	D	Q	I	T		E	V		K			N		K	15
	A/Ghana/FS-14-1025/2014Nov	A		S		N	M			T	T		T	D	Q	I			E	V		K			N		K	15
	A/Ghana/FS-14-1069/2014Dec	A		S		N	M			T	T		T	D	Q	I		V	E	V		K			N		K	16
	A/Ghana/Dili-0567/2014Jun	A		S		N	M			T	T		T	D	Q	I		V	E	V		K			N		K	16

^aOnly amino acid differences found in virus isolates from Africa are shown