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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Circ Genom Precis Med. 2018 Mar;11(3):e001901. doi: 10.1161/CIRCGEN.117.001901

Figure 1.

Figure 1

cis eQTL for PRKCA in the human left ventricle. A, Human left ventricular free wall PKCα transcript abundance versus rs9912468 genotype in patients without (n = 136) and with (n =177) heart failure. The minor allele at rs9912468 (forward strand G) is associated with lower PKCα transcript levels (joint effects p = 1×10−41). B, Western blot comparing left ventricular PKCα protein levels in rs9912468 major allele homozygotes (CC, blue) and minor allele homozygotes (GG, red) in a subset of the patients in A. C, Quantitative analysis using densitometry (n=20) demonstrated reduced PKCα protein in minor allele homozygotes (P < 0.001) D, PKCα transcript and protein levels assessed in the same subjects showed strong correlation, indicating that PKCα transcript level is an accurate surrogate for protein level in the human left ventricle. E, Association between rs9912468 genotype and PKCα transcript levels in multiple human tissues based on GTEx data (*Bonferroni P < 0.05). Associations are strongest in left ventricle.