Table 3.
Results of 24 h significance testing for differences between groups extracted from the polynomial curve of best-fit smoothing models.
| Analyte | Difference between groups |
|
|---|---|---|
| Mean difference | 95% confidence interval | |
| Routine laboratory tests | ||
| White blood cell count | 0.711 | −1.67, 3.1 |
| Neutrophils | 0.318 | −2.27, 2.93 |
| Lymphocytes | 0.0238 | −0.477, 0.504 |
| Monocytes | 0.0504 | −0.325, 0.399 |
| Creatinine | −0.604 | −17, 15.3 |
| Haemoglobin | 1.98 | −7.55, 11 |
| Platelets* | −26.7 | −52.3, −3.74 |
| Complement cascade components | ||
| C2 | −1028 | −6632, 4740 |
| C4b | −766 | −2311, 766 |
| C5 | −26,221 | −62,308, 9688 |
| C5a | 1131 | −653, 2986 |
| C9 | 210 | −364, 793 |
| Factor D | 12.8 | −26.5, 52.9 |
| MBL | −427 | −3089, 2298 |
| C1q | 1.62 | −13.1, 16.3 |
| C3* | 25.9 | 4.46, 47.8 |
| C3b/iC3b | 352 | −232, 958 |
| C4 | 23.4 | −118, 159 |
| Factor B | 14.8 | −38.9, 68.9 |
| Factor H | 18 | −53.4, 90 |
| Factor I | 394 | −233, 1011 |
| Properdin | −1.32 | −7.17, 4.47 |
| Cytokines/chemokines | ||
| Eotaxin* | −36.8 | −74.2, 0.384 |
| GM-CSF | −6.8 | −27.7, 14.1 |
| IFN-α2 | −17.7 | −65, 30.8 |
| IFN-γ* | −14.3 | −27.5, −2.1 |
| IL-10 | 16.7 | −9.57, 44.2 |
| IL-12p40 | −8.06 | −24.6, 8.44 |
| IL-12p70 | −4.85 | −17.8, 8.01 |
| IL-13 | −20.6 | −47.9, 6.58 |
| IL-15 | −1.41 | −4.73, 1.98 |
| IL-17 | −0.767 | −1.84, 0.364 |
| IL-1rα | 19.2 | −51.4, 86.5 |
| IL-1b | −1.25 | −4.04, 1.68 |
| IL-2 | −6.96 | −15.3, 1.58 |
| IL-4 | −5.45 | −25.9, 16.1 |
| IL-5 | −7 | −16, 2.42 |
| IL-6 | 25.8 | −28.9, 84.1 |
| IL-7 | −6.51 | −13.7, 0.943 |
| IL-8 | 5.82 | −3.05, 14.3 |
| IP-10 | −4.05 | −213, 213 |
| MCP-1 | −13.6 | −153, 131 |
| MIP-1α | −2.67 | −5.76, 0.473 |
| MIP-1β | −8.25 | −18.8, 2.43 |
| TNFα | −1.45 | −5.76, 2.87 |
| Other inflammatory markers | ||
| hs-CRP | 3261 | −2924, 870 |
| MMP9* | 72,435 | 6401, 1,35,310 |
*
p < 0.05. hs-CRP, high-sensitivity C-reactive protein; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; IL, interleukin; IP-10, interferon gamma-induced protein 10; MBL, mannose-binding lectin; MCP-1, monocyte chemoattractant protein 1; MIP, macrophage inflammatory protein; MMP-9, matrix metallopeptidase-9; TNF-α, tumour necrosis factor alpha.