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. Author manuscript; available in PMC: 2018 Mar 19.
Published in final edited form as: Histol Histopathol. 2017 May 25;33(1):1–10. doi: 10.14670/HH-11-905

Figure 2. The Potential Oncogenic Roles of LIPG.

Figure 2

A) LIPG expression may be activated through microenvironmental crosstalk and signaling induced by adipokines such as IL-6 and leptin. B) Lipid precursors supplied to the cell through LIPG-mediated cleavage of HDL can promote proliferation and growth in cancer cells. C) LIPG catalysis of HDL releases Sphingosine-1-phosphate (S1P), which binds to sphingosine-1-phosphate receptors resulting in the phosphorylation and activation of Akt and eNOS. These pathways have been shown to promote endothelial cell migration, tube formation, and angiogenesis. D) Inflammatory signals can induce NFκB-mediated activation of LIPG transcription, which may have major implications in cancer development and progression. This figure was produced using Servier medical art, available from http://www.servier.com/Powerpoint-image-bank.