Fig 2. Functional distribution of deletion mutants that are highly sensitive to ZnONPs and AgNPs.

(A) Clustering of the 59 most sensitive deletion mutant strains to 1 mg/mL ZnONPs reveal that mutants lacking genes involved in membrane and transmembrane transport, ion homeostasis and transport, and cell organization of biogenesis encompass the significantly enriched groups. (B) Clustering of the 96 most sensitive deletion mutant strains to 0.095 mg/mL AgNPs indicate that mutants lacking genes involved in transcription, cellular respiration, and endocytosis and vesicular transport represent the significantly enriched groups.