Skip to main content
. 2018 Mar 19;13(3):e0194220. doi: 10.1371/journal.pone.0194220

Table 1. General parameter symbols, definitions, baseline values, sensitivity analysis ranges, and sources.

General parameters—identical for progressions assumptions A, B, C, and D
Symbol Definition Main parameter estimate Range used in sensitivity analysis Source
γ Rate of progression from the acute infection stage to chronic infection with CD4 ≥ 500 (year-1) 4.80 [32]
σ1 Rate of progression for ART-naive individuals from CD4 ≥ 500 to 350 ≤ CD4 < 500 (year-1) 1.35 [17]
σ2 Rate of progression for ART-naive individuals from 350 ≤ CD4 < 500 to 200 ≤ CD4 < 350 (year-1) 0.33 [17]
σ3 Rate of progression for ART-naive individuals from 200 ≤ CD4 < 350 to CD4 < 200 (year-1) 0.27 [17]
c Mean number of partners per year 2.3 [33]
κ Proportion of partnerships in which condoms are used 45.9% [34]
ν Efficacy of condoms in reducing transmissibility in a partnership 78% [31, 37, 38]
ω Efficacy of ART in reducing HIV transmissibility 92% 50–100% [28]
θ ART dropout rate (year-1) 0.10 0.05–0.20 [12, 13, 35, 36]
μ Inverse of the sexual life expectancy (year-1) 1/ 50 = 0.02 [39]
η Efficacy of ART in reducing HIV-attributable mortality 90% [30]
αAc Additional mortality attributable to HIV infection during acute infection (year-1) 0.00 Assumed negligible
αI1 Additional mortality attributable to HIV infection in ART-naive individuals with CD4 ≥ 500 (year-1) 0.007 [29]
αI2 Additional mortality attributable to HIV infection in ART-naive individuals with 350 ≤ CD4 < 500 (year-1) 0.006 [29]
αI3 Additional mortality attributable to HIV infection in ART-naive individuals with 200 ≤ CD4 < 350 (year-1) 0.007 [29]
αI4 Additional mortality attributable to HIV infection in ART-naive individuals with CD4 < 200 (year-1) 0.262 [29]
RRAc Relative infectivity of individuals in the acute phase of infection vs. chronic ART-naive CD4 ≥ 350 11.7 [32]
RRI3 Relative infectivity of infected ART-naive individuals with 200 ≤ CD4 < 350 vs. CD4 ≥ 350 1.6 [28]
RRI4 Relative infectivity of infected ART-naive individuals with CD4 < 200 vs. CD4 ≥ 350 5.0 [28]