Table 2. Assumption-specific parameter symbols, definitions, baseline values, and sources.
Assumption-specific parameters and variables | ||||||
---|---|---|---|---|---|---|
Symbol | Definition | Estimate for each assumption | Source | |||
A | B | C | D | |||
ε | ART initiation rate for ART-naives and for dropouts (year-1) | 0.0651 | 0.0641 | 0.0614 | 0.0641 | Fitted |
ρ | Transmission probability per partnership with chronically infected ART-naive individuals with CD4 ≥ 350 | 0.0361 | 0.0356 | 0.0343 | 0.0359 | Fitted (range: 0.012–0.145 [40]) |
τ | Relative disease progression rate for individuals on ART compared to ART-naive | 0.1 | 0 | 0 | 0 | [5, 12, 30] |
ψ1 | Rate of progression for individuals on ART from 350 ≤ CD4 < 500 to CD4 ≥ 500 (year-1) | 0 | 0 | 0.550 | 0 | [18] |
ψ2 | Rate of progression for individuals on ART from 200 ≤ CD4 < 350 to 350 ≤ CD4 < 500 (year-1) | 0 | 0 | 0.408 | 0 | [18] |
ψ3 | Rate of progression for individuals on ART from CD4 < 200 to 200 ≤ CD4 < 350 (year-1) | 0 | 0 | 0.479 | 0 | [18] |
p | Proportion of individuals dropping out from A4 that move to D2 | 0 | 0 | 0 | 0.5 | [13] |
δ | Relative disease progression rate for ART dropouts compared to ART-naive individuals | 1.0 | 1.0 | 1.0 | 2.0 | [5, 12, 13] |