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. 2018 Mar 19;13(3):e0194220. doi: 10.1371/journal.pone.0194220

Table 2. Assumption-specific parameter symbols, definitions, baseline values, and sources.

Assumption-specific parameters and variables
Symbol Definition Estimate for each assumption Source
A B C D
ε ART initiation rate for ART-naives and for dropouts (year-1) 0.0651 0.0641 0.0614 0.0641 Fitted
ρ Transmission probability per partnership with chronically infected ART-naive individuals with CD4 ≥ 350 0.0361 0.0356 0.0343 0.0359 Fitted (range: 0.012–0.145 [40])
τ Relative disease progression rate for individuals on ART compared to ART-naive 0.1 0 0 0 [5, 12, 30]
ψ1 Rate of progression for individuals on ART from 350 ≤ CD4 < 500 to CD4 ≥ 500 (year-1) 0 0 0.550 0 [18]
ψ2 Rate of progression for individuals on ART from 200 ≤ CD4 < 350 to 350 ≤ CD4 < 500 (year-1) 0 0 0.408 0 [18]
ψ3 Rate of progression for individuals on ART from CD4 < 200 to 200 ≤ CD4 < 350 (year-1) 0 0 0.479 0 [18]
p Proportion of individuals dropping out from A4 that move to D2 0 0 0 0.5 [13]
δ Relative disease progression rate for ART dropouts compared to ART-naive individuals 1.0 1.0 1.0 2.0 [5, 12, 13]