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. 2018 Mar 19;13(3):e0194620. doi: 10.1371/journal.pone.0194620

Fig 5. PLGA vaccination elicited potent systemic anti-MPT83 IgG responses.

Fig 5

C57BL/6 mice (n = 3) were immunised with 1 mg PLGA vaccine, three times at two-weekly intervals. 28 days following final immunisation anti-MPT83 IgG was detected by ELISA in the serum of mice immunised (A) i.n or s.c with TDB adjuvanted vaccine, or (B) s.c with MPL adjuvanted vaccine. Titre was determined as the highest dilution giving an absorbance greater than the mean absorbance of a 1:100 dilution of adjuvant only immunised mouse sera. The data are the means ± SEM and are representative of two independent experiments. Statistical significance was calculated by ANOVA with Bonferroni post-hoc comparison (*p<0.05, **p<0.01).