Table 5.

Diagnostic performances of standard-dose (SD) and low-dose (LD) CT

	Reviewer 1		p	Reviewer 2		p
	SDCT	LDCT		SDCT	LDCT
Total
Sensitivity	96.7 (88.5–99.6)	94.0 (85.4–98.4)	0.77	100 (94.0–100)	98.5 (92.0–100)	0.96
Specificity	95.6 (87.3–99.1)	95.7 (88.0–99.1)	0.70	97.0 (89.5–99.6)	95.7 (85.0–99.1)	0.96
PPV	95.1 (86.5–98.3)	95.5 (87.4–98.5)	0.75	96.8 (88.5–99.2)	95.7 (87.9–98.5)	0.90
NPV	96.9 (89.0–99.2)	94.4 (86.8–97.8)	0.77	100 (NA)	98.5 (90.5–100)	0.99
Accuracy	96.0 (91.0–98.7)	94.9 (89.7–97.9)	0.50	98.4 (94.5–99.8)	97.1 (92.7–99.2)	0.77
BMI Group 1
Sensitivity	100 (78.2–100)	94.1 (71.3–100)	0.95	100 (78.2–100)	100 (80.5–100)	1.0
Specificity	100 (83.2–100)	100 (80.5–100)	1.0	100 (83.2–100)	(80.5–100)	1.0
PPV	100 (NA)	100 (NA)	1.0	100 (NA)	100 (NA)	1.0
NPV	100 (NA)	94.4 (71.7–99.1)	0.95	100 (NA)	100 (NA)	1.0
Accuracy	100 (90.0–100)	97.1 (84.7–99.9)	1.0	100 (90.0–100)	100 (89.7–100)	1.0
BMI Group 2
Sensitivity	97.0 (84.2–99.9)	97.1 (85.1–99.9)	0.49	100 (89.4–100)	100 (90.0–100)	1.0
Specificity	92.6 (75.7–99.1)	93.1 (77.2–99.2)	0.66	96.3 (81.0–99.9)	93.1 (77.2–99.2)	0.95
PPV	94.1 (80.8–98.4)	94.4 (81.7–98.5)	0.65	97.1 (82.8–99.6)	94.6 (82.1–98.5)	0.95
	NPV	96.2 (78.3–99.4)	96.6 (80.2–99.5)	0.51	100 (NA)	100 (NA)	1.0
Accuracy	95.0 (85.8–98.9)	95.3 (86.6–98.9)	0.73	98.3 (90.8–99.9)	96.9 (88.7–99.5)	0.94
BMI Group 3
Sensitivity	91.2 (61.5–99.8)	86.7 (59.5–98.3)	0.81	100 (73.5–100)	93.3 (68.1–99.8)	0.91
Specificity	94.7 (74.0–99.9)	95.8 (78.9–99.9)	0.58	94.7 (74.0–99.9)	95.8 (78.9–99.9)	0.58
PPV	91.2 (61.8–98.7)	92.9 (65.4–98.9)	0.57	92.3 (64.0–98.8)	93.3 (67.2–99.0)	0.53
NPV	94.7 (73.3–99.2)	92.0 (75.9–97.7)	0.80	100 (NA)	95.8 (77.6–99.4)	0.89
Accuracy	93.5 (78.1–99.1)	92.3 (77.7–97.9)	0.78	96.8 (84.2–100)	94.9 (82.3–99.3)	0.84

Data are percentage and 95% confidence interval in parenthesis. BMI, body mass index; NA, not applicable; NPV, negative predictive value; PPV, positive predictive value;