Table 2.
Performance of individual parameters in predicting pCR, measured from statistically significant ROC curves with cut-offs determined on the basis of Youden index
| Variable | AUC | SE | Cut-off | Sensitivity (%) | Specificity (%) |
| Contrast | 0.722 | 0.0851 | >3385 | 46.7 | 93.1 |
| Correlation | 0.715 | 0.0848 | ≤1.465 × 10−4 | 60.0 | 82.8 |
| Sum variance | 0.674 | 0.0813 | >7,4770 | 86.7 | 51.7 |
| Difference variance | 0.699 | 0.0874 | ≤2.46 × 10−5 | 46.7 | 89.7 |
| Difference entropy | 0.713 | 0.0859 | >4.751 | 60.0 | 82.8 |
| LRE | 0.676 | 0.0806 | >1.247 | 80 | 58.6 |
| LRHGE | 0.708 | 0.0777 | >2,4213 | 93.3 | 55.2 |
AUC, area under the ROC curve; SE,standard error;LRE, long run emphasis, LRHGE, low run high grey level emphasis; pCR+Smith’s Grade = 5; pCR−, Smith’s Grade < 5; pCRN+, pCR+ plus either complete absence of residual nodal metastases or presence of nodal micrometastasis; pCRN−, Smith’s Grade < 5 and any other status of axillary lymph node metastases.